Baseado nos livros Bad Blood, de Vic Parsons, e The Gift of Death, de Andre Picard, a série narra o surgimento do HIV / AIDS e da Hepatite C nos bancos de sangue da Cruz Vermelha Canadense no início dos anos 80. Unspeakable chronicles the emergence of HIV and Hepatitis C in Canada in the early 1980s and the tragedy that resulted after thousands of people were infected by tainted blood. One of the largest medical disasters in Canadian history, the blood scandal triggered a federal inquiry and precedent-setting lawsuit resulting in billions of dollars in compensation to victims.